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|Hematological Neoplasms
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Revision as of 22:00, 27 December 2025


<span class="mwt-editable mwt-comment" id="R1766923378676" " draggable="false" contenteditable="true">Hides title of Main Page

Welcome to Neoplasm.org

Neoplasm.org is a collaborative, open-access knowledge base dedicated to the rapid dissemination of oncology clinical trial results and evidence-based treatment regimens.

Modeled after the collaborative spirit of the medical community, our mission is to translate complex research into actionable clinical insights—free of charge and accessible to everyone, from oncologists and researchers to students and patients.

Guidelines Solid Tumors Hematological Neoplasms

Solid Tumors
Breast Oncology
Early breast cancer (EBC)
EBC, NOS HR-positive EBC HER2-positive EBC HER2-low EBC
HR-positive and HER2-positive EBC Early triple-negative breast cancer (eTNBC)
Metastatic breast cancer (MBC)
MBC, NOS HR-positive MBC HER2-positive MBC HER2-low MBC
HR-positive and HER2-positive MBC Metastatic triple-negative breast cancer (mTNBC) CNS metastases
Breast cancer with molecular alterations
Testfdasfjifojifjo PI3K pathway-altered Breast cancer
Dermatologic Oncology
Melanoma
Melanoma, NOS BRAF-mutated Melanoma KIT-mutated Melanoma NRAS-mutated Melanoma
Uveal melanoma
Non-melanoma skin cancer (NMSC)
Cutaneous BCC Cutaneous SCC Merkel cell carcinoma (MCC)
Endocrine Oncology
Other endocrine cancers
Adrenocortical carcinoma Neuroendocrine tumor (NET) Neuroendocrine carcinoma (NEC) Pancreatic NET
Pheochromocytoma
Thyroid cancer without molecular alterations
Thyroid cancer, NOS Anaplastic thyroid cancer (ATC) Differentiated thyroid cancer (DTC) Medullary thyroid cancer (MTC)
Thyroid cancer with molecular alterations
BRAF-mutated Thyroid cancer RET-positive Thyroid cancer
Gastrointestinal Oncology
Upper GI tract
Esophageal cancer, NOS Esophageal adenocarcinoma Esophageal squamous cell carcinoma (ESCC) Gastric cancer, NOS
HER2-positive gastric cancer
Lower GI tract
Anal cancer Appendiceal tumor Colon cancer, NOS RAS wild-type colon cancer
Colorectal cancer (CRC), NOS BRAF-mutated CRC HER2-positive CRC MSI-H or dMMR CRC
RAS wild-type CRC Rectal cancer Small bowel adenocarcinoma
Hepatobiliary cancer
Biliary tract cancer Cholangiocarcinoma Gallbladder cancer Hepatocellular carcinoma (HCC)
Periampullary adenocarcinoma
Pancreatic cancer
Pancreatic adenocarcinoma, NOS BRCA-mutated Pancreatic adenocarcinoma NRG1-positive Pancreatic adenocarcinoma Pancreatic NET
Genitourinary Oncology
Kidney cancer
Renal cell carcinoma (RCC), NOS Clear cell RCC (ccRCC) Non-clear cell RCC (nccRCC) Papillary RCC
Sarcomatoid RCC VHL-associated RCC
Male genital tract
Penile cancer Prostate cancer, NOS Prostate cancer, HRD-positive Testicular cancer
Urinary tract cancer
Urothelial carcinoma, NOS Bladder cancer Upper tract urothelial carcinoma (UTUC)
Gynecologic Oncology
Ovarian cancer
High-grade serous ovarian cancer (HGSOC) Low-grade serous ovarian cancer (LGSOC) Ovarian cancer, BRCA-mutated
Other gynecologic cancer
Cervical cancer Endometrial cancer Gestational trophoblastic neoplasia Vulvar cancer
Head & Neck Oncology
Head and neck cancer Nasopharyngeal carcinoma (NPC) HPV+ Oropharyngeal cancer
Mesothelioma
Malignant peritoneal mesothelioma (MPEM) Malignant pleural mesothelioma (MPM)
Neuro-Oncology
Primary central nervous system (CNS) malignancies
Anaplastic glioma Craniopharyngioma Diffuse midline glioma New Glioblastoma (GBM)
Low-grade glioma Meningioma Subependymal giant cell astrocytoma (SEGA)
Secondary CNS malignancies
CNS carcinoma CNS leukemia CNS lymphoma CNS melanoma
Sarcoma
Bone sarcoma
Bone sarcoma, NOS Ewing sarcoma Giant-cell tumor of bone Osteosarcoma
Soft tissue sarcoma
Soft tissue sarcoma (STS), NOS Alveolar soft part sarcoma (ASPS) Dermatofibrosarcoma protuberans Desmoid tumor
Epithelioid sarcoma Gastrointestinal stromal tumor (GIST) Inflammatory myofibroblastic tumor (IMT) Leiomyosarcoma (LMS)
Liposarcoma PEComa Rhabdomyosarcoma (RMS) Tenosynovial giant cell tumor (TGCT)
Vascular sarcoma
Vascular sarcoma, NOS Angiosarcoma Kaposi sarcoma (KS)
Thoracic Oncology
Non-small cell lung cancer (NSCLC) without driver alterations
NSCLC, NOS Nonsquamous NSCLC Squamous NSCLC PD-L1-positive NSCLC
CNS metastases
NSCLC with driver alterations
ALK-positive NSCLC BRAF-mutated NSCLC c-Met-positive NSCLC EGFR-mutated NSCLC
HER2-mutated NSCLC KRAS-mutated NSCLC MET-mutated NSCLC NRG1-positive NSCLC
RET-positive NSCLC ROS1-positive NSCLC
Other thoracic cancer
Malignant pleural mesothelioma (MPM) Small cell lung cancer (SCLC) Thymoma
Site-agnostic
BRAF EGFR ERBB2 (HER2) ERBB3 (HER3)
MSI-H or dMMR NTRK RET SMO or PTCH-1 (Hedgehog)
TMB-H Carcinoma of unknown primary (CUP)

Malignant Hematology
Acute leukemias
Acute leukemia, KMT2A-rearranged Acute myeloid leukemia (AML) AML, FLT3-positive AML, IDH-mutated
AML, NPM1-mutated Acute promyelocytic leukemia (APL) B-cell acute lymphoblastic leukemia (B-ALL) B-ALL, Ph+
T-cell acute lymphoblastic leukemia (T-ALL) Blastic plasmacytoid dendritic cell neoplasm (BPDCN) CNS leukemia
Myeloproliferative neoplasms and myelodysplastic syndromes
Chronic myeloid leukemia (CML) Chronic myelomonocytic leukemia (CMML) Essential thrombocythemia (ET) Hypereosinophilic syndrome (HES)
Myelodysplastic syndrome (MDS) Primary & secondary myelofibrosis (PMF/SMF) Myeloproliferative neoplasm, accelerated phase (MPN-AP) New Polycythemia vera (PV)
Systemic mastocytosis
Aggressive lymphomas
Burkitt lymphoma (BL) or Burkitt-like lymphoma Classical Hodgkin lymphoma (cHL) CNS lymphoma Diffuse large B-cell lymphoma (DLBCL)
Gastric DLBCL New High-grade B-cell lymphoma (HGBL) HIV-associated lymphoma Mantle cell lymphoma (MCL)
Mediastinal gray-zone lymphoma (MGZL) Primary mediastinal B-cell lymphoma (PMBL) Transformed lymphoma (TL)
Indolent lymphomas
Chronic lymphocytic leukemia (CLL/SLL) Follicular lymphoma (FL) Hairy cell leukemia (HCL) Hodgkin lymphoma, nodular lymphocyte-predominant (NLP-HL)
Indolent lymphoma (iNHL) MALT lymphoma Marginal zone lymphoma (MZL) Waldenström macroglobulinemia (WM/LPL)
Plasma cell dyscrasias
Light-chain (AL) amyloidosis Multiple myeloma (main page) MM, induction MM, consolidation & maintenance
MM, relapsed/refractory Plasma cell leukemia (PCL) POEMS syndrome Smoldering multiple myeloma (SMM)
T-cell and NK-cell neoplasms
Adult T-cell leukemia-lymphoma (ATLL) Anaplastic large cell lymphoma (ALCL) Cutaneous T-cell lymphoma (CTCL) Extranodal NK- and T-cell lymphoma, nasal type (ENKTCL-NT
Large granular lymphocytic (LGL) leukemia NK- and T-cell lymphoma (NKTCL) Peripheral T-cell Lymphoma (PTCL) T-cell acute lymphoblastic lymphoma (T-LBL)
T-cell prolymphocytic lymphoma (T-PLL)
Lymphoproliferative disorders
Castleman disease Post-transplant lymphoproliferative disorder (PTLD)
Histiocytic disorders
Erdheim-Chester disease (ECD) Hemophagocytic lymphohistiocytosis (HLH) Langerhans cell histiocytosis (LCH) Rosai-Dorfman-Destombes disease

Pediatric Neoplasms
Pediatric CNS malignancies
Low-grade glioma High-grade glioma Medulloblastoma


Pediatric hematologic neoplasms
B-cell acute lymphoblastic leukemia (B-ALL) B-ALL, Ph+ T-cell acute lymphoblastic leukemia (T-ALL) Acute myeloid leukemia (AML)
Anaplastic large cell lymphoma (ALCL) Chronic myeloid leukemia (CML) Juvenile myelomonocytic leukemia (JMML)
Classical Hodgkin lymphoma (cHL) Non-Hodgkin lymphoma (NHL)
Pediatric solid tumors
Epithelioid sarcoma Ewing sarcoma Hepatoblastoma Neuroblastoma
Osteosarcoma Retinoblastoma Rhabdomyosarcoma Wilms tumor

Transplant and Immune Effector Cells (IECs)
Stem cell mobilization Allogeneic HSCT Autologous HSCT Chimeric antigen receptor T cells (CAR-T)
Graft versus host disease (GVHD) Hepatic veno-occlusive disease (VOD/SOS)

Classical Hematology
Hemostasis and thrombosis
Acquired coagulopathy Acquired thrombotic thrombocytopenic purpura (aTTP) Antiphospholipid antibody syndrome (APLAS) Congenital thrombotic thrombocytopenic purpura (cTTP)
Hemophilia A Hemophilia B Heparin-induced thrombocytopenia (HIT) Hereditary hemorrhagic telangiectasia (HHT)
Inherited thrombophilia Thrombotic microangiopathy (TMA) Venous thromboembolism (VTE) von Willebrand disease (vWD)
Cytopenias
Aplastic anemia Autoimmune cytopenia Immune thrombocytopenia (ITP) Thrombocytopenia in liver disease
WHIM syndrome
Hemolytic disorders and Hemoglobinopathies
Atypical hemolytic uremic syndrome (aHUS) Warm autoimmune hemolytic anemia (WAIHA) Cold agglutinin disease (CAD) Paroxysmal nocturnal hemoglobinuria (PNH)
Pyruvate kinase deficiency (PKD) Beta thalassemia Sickle cell disease (SCD)

Additional Information

What We Do

In the fast-moving field of oncology, keeping up with the latest data is a challenge. Neoplasm.org serves as a "living textbook" where:

  • Clinical Trial Results are summarized and categorized for quick reference.

  • Treatment Regimens are detailed with evidence-backed citations and toxicity profiles.

  • Collaborative Note-taking allows experts to contribute clinical pearls and real-world experience.

Why Neoplasm.org?

Unlike static journals, our platform is built for speed and collaboration. Using modern collaborative tools (powered by Docmost), we allow credentialed contributors to update notes in real-time as new data emerges from ASCO, ESMO, and major journals.

  • Free to the Public: Information that saves lives should not be behind a paywall.

  • Clinically Structured: Organized by disease site, histology, and stage for maximum utility during rounds or tumor boards.

  • Evidence-Based: Every note is rooted in published clinical evidence.

Join the Collaboration

Neoplasm.org is built by the oncology community, for the oncology community. Whether you are adding a new regimen or refining a trial summary, your contributions help build a more transparent and informed world for cancer care.

Disclaimer: Neoplasm.org is an educational and research resource. Clinical decisions should always be made by a qualified healthcare professional.